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Diabetes mellitus is an inability to regulate blood glucose caused by a loss of insulin production (Type I) or inadequate insulin supply or resistance (Type II). Dogs need insulin injections to manage diabetes. Sometimes special diets may help manage the disease. Response to insulin needs to be monitored to ensure adequate dosing and to avoid hypoglycemia caused by insulin overdose. Blood glucose curves are most commonly used for this including: in-clinic blood glucose curves, home glucose curves with hand-held glucometers and continuous glucose monitoring systems. Urine glucose testing and fructosamine testing may also be used to manage the disease. Hypoglycemia is the consequence of administering too much insulin compared to the amount of food ingested. Signs can range from lethargy to seizures and coma. It can be managed acutely with administration of sugar syrup to the gums but more severely affected dogs will need IV dextrose solutions.
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Diabetes insipidus results in excessive drinking and urination. As many conditions cause these signs, a number of diagnostic tests including bloodwork and urinalysis need to be performed to rule out other causes. After more common causes are ruled out, a modified water deprivation test can confirm disease and an MRI or therapeutic trial can be performed. Diabetes insipidus results from reduced production of ADH from the brain or reduced sensitivity to ADH in the kidney. Treatment depends on the cause of the disease either replacing the lack of ADH with a synthetic replacement or using a hydrochlorothiazide and a low salt diet to decrease urine production.
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Diabetes insipidus is rare in cats and is characterized by excessive drinking and the production of enormous volumes of extremely dilute urine. Despite drinking large volumes of water, the cat can become dehydrated from urinating so much. Increased drinking and urination are common signs of several other health conditions, so it is essential that several diagnostic tests be performed to diagnose diabetes insipidus. While the condition is rarely curable, it is usually successfully controlled.
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Various conditions can cause increased thirst (polydipsia) and urination (polyuria). Based on your pet's history and a thorough physical examination, your veterinarian will recommend diagnostic testing to determine the cause. This handout describes several tests that can be performed along with the conditions the results from these tests may indicate.
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There are four major hormonal diseases in ferrets. This handout covers adrenal gland disease and diabetes mellitus. Adrenal gland disease occurs in a large number of ferrets in North America, while diabetes mellitus is a rare, but important problem.
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Although uncommon, cats and dogs are at risk for several diseases during the two months of their pregnancy. Pre-eclampsia occurs if the mothers cannot keep up with the demand for calcium to produce bones and milk. Gestational diabetes can occur due to high concentrations of hormones and result in increased drinking, urination, inappropriate weight loss and lethargy. Mastitis is a bacterial infection of one or more mammary glands that is contracted either through the blood (sepsis) or from the external environment from unsanitary conditions and/or injury from babies’ teeth or nails. Retained placentas can occur and will result in lethargy, pyrexia and abnormal vulvar discharge. Be aware of the signs, symptoms and management for all four conditions.
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Cats with diabetes have the potential to go into remission where they may no longer need to receive insulin. Factors that can affect the likelihood of remission include the type of insulin given, your cat's diet, and how long your cat has been diabetic. It is important to recognize the signs of hypoglycemia, as they may be your first indication of remission.
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Pituitary macroadenomas are large tumors of the pituitary gland that are either functional (secrete hormones) or non-functional (do not secrete hormones). The clinical signs depend on the type of macroadenoma, though become severe over time in either case. Diagnosis requires specialized CT or MRI imaging. This handout explains the effects of macroadenomas in cats and the treatment options available.
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This condition takes its name from the comparable human condition, metabolic syndrome. It is a complex, multi-factorial problem involving numerous body systems. In humans it increases the risk of stroke, heart attack, diabetes and other potentially serious medical disorders.
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Pituitary macroadenomas are large tumors of the pituitary gland that are either functional (secrete hormones) or non-functional (do not secrete hormones). The most common functional pituitary macroadenoma in the dog secretes the hormone ACTH, causing increased cortisol levels and Cushing’s disease. Non-functional macroadenomas cause clinical signs through compression of nearby structures resulting in vision changes, diabetes insipidus, and neurologic disorders. This handout explains the effects of these tumors on dogs, how they are diagnosed, and the treatment options available.